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REVIEW ARTICLE
Year : 2017  |  Volume : 1  |  Issue : 6  |  Page : 28-30

The bacteremia antibiotic length actually needed for clinical effectiveness research program (balance.ccctg.ca)


Sunnybrook Hospital, the University of Toronto, Toronto, Ontario, Canada

Correspondence Address:
Robert Fowler
MDCM, MS (Epi), FRCP(C), 2075 Bayview Avenue, Room D478, Sunnybrook Hospital, Toronto, Ontario
Canada
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2543-1854.219135

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A multitude of global health organizations have declared antimicrobial resistance a threat to health, based on rapidly increasing resistance rates and declining new drug development. Up to 30%–50% of antibiotic use is estimated to be inappropriate, and excessive durations of treatment are the greatest contributor to inappropriate use. A landmark trial in critically ill patients with ventilator-associated pneumonia showed that mortality and relapse rates were noninferior in patients who received 8 versus 15 days of treatment, but similar evidence is lacking for the treatment of patients with bloodstream infection, which affects 15% of critically ill patients. The Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) research program was initiated to provide evidence-based guidance on this question.


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