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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 3  |  Page : 104-108

Study of ischemia-modified albumin as a biomarker in critically ill patients with sepsis


1 MBBS Student, Narayana Medical College and Hospital, Chintareddypalem, Nellore, A.P, India
2 Head of Clinical Services, Department of Emergency Medicine, Narayana Medical College and Hospital, Chintareddypalem, Nellore, A.P, India
3 Department of Microbiology, Narayana Medical College and Hospital, Chintareddypalem, Nellore, A.P, India

Correspondence Address:
Raghu K
Department of Emergency Medicine, Narayana Medical College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sccj.sccj_16_19

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Background: Critical ill will be accessed by sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation. Circulating ischemia-modified albumin is generated under ischemic and oxidative conditions and it reflects the disease severity. Aims and Objectives: The objective of this study is to compare the sensitivity and rapidness of Ischemia Modified Albumin as a biomarker with that of an already established biomarker, C-Reactive Protein in patients identified as critically ill septic patients. Materials and Method: A group of 30 subjects were identified using qSOFA as patients suffering from sepsis and their blood samples were taken. These samples were tested for ischemia modified albumin, an inflammatory biomarker, and each sample was also assessed for CRP. Similarly, control patients were assessed for IMA and CRP as well. Results: The results showed that IMA and CRP were both significantly elevated in sepsis, with mean values of 103.77 ± 15.61 ABSU for IMA and 35.58 ± 19.82 mg/L for CRP. However, it was found that the test performed for serum IMA is a quicker and more cost-effective test than that of CRP. Conclusion: This methodology will lead to the usage of a cheaper and more effective diagnostic and prognostic tool for patients succumbed to sepsis.


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