|Year : 2017 | Volume
| Issue : 6 | Page : 17-18
Society of critical care medicine discovery: Collaborative critical care research network
Jonathan E Sevransky1, Ognjen Gajic2
1 Emory University School of Medicine, Department of Medicine, Atlanta, Georgia
2 Mayo Clinic, Department of Critical Care, Rochester, Minnesota, USA
|Date of Web Publication||23-Nov-2017|
Jonathan E Sevransky
1364 Clifton Road, Suite D226 Atlanta
Source of Support: None, Conflict of Interest: None
Large-scale clinical trials networks are best suited for understanding how care is delivered, generating evidence to minimize unnecessary heterogeneity of patient care, and testing different care patterns and medications to improve clinical outcomes. Discovery, the Critical Care Research Network, was launched in 2017 as a combined effort of the United States Critical Illness and Injury Trials (USCIIT), the Critical Care Pharmacotherapy Trials Network (CCPTN), and the Society of Critical Care Medicine (SCCM). In collaboration with our colleagues we hope to contribute evidence to help improve the care of the critically ill and injured
Keywords: Clinical trials, critical care, intensive care, observational studies
|How to cite this article:|
Sevransky JE, Gajic O. Society of critical care medicine discovery: Collaborative critical care research network. Saudi Crit Care J 2017;1, Suppl S2:17-8
|How to cite this URL:|
Sevransky JE, Gajic O. Society of critical care medicine discovery: Collaborative critical care research network. Saudi Crit Care J [serial online] 2017 [cited 2018 Jun 23];1, Suppl S2:17-8. Available from: http://www.sccj-sa.org/text.asp?2017/1/6/17/219131
Critical illness and injury are major causes of death and disability worldwide. Care of these critically ill patients is delivered by teams of specially trained clinicians care for these patients in Intensive Care Units (ICUs). While decades of experience have improved patient care, substantial heterogeneity of practice still occurs within ICUs as well as among ICUs. Large-scale networks are best suited for understanding how care is delivered, generating evidence to minimize unnecessary heterogeneity of patient care, and testing different care patterns and medications to improve clinical outcomes., These networks ideally would have clinicians who span the continuum from emergency care to posthospital care and would include members of all disciplines.
Discovery, the Critical Care Research Network, was launched in 2017 as a combined effort of the United States Critical Illness and Injury Trials (USCIIT), the Critical Care Pharmacotherapy Trials Network (CCPTN), and the Society of Critical Care Medicine (SCCM). USCIIT was launched in 2008, eventually achieving enrollment of more than 10,000 patients into studies, more than 30 publications, and more than 25 million dollars of grant funding. CCPTN was founded in 2010, dedicated to scientific investigations in critical care pharmacotherapy. By 2015, more than 100 site investigators from the United States and Canada contributed to CCPTN studies, yielding approximately 30 manuscripts and 10 abstracts. Together, these groups have formally joined with SCCM, a multiprofessional critical care organization with more than 16,000 members, to form Discovery.
SCCM appointed a diverse group of members to form the Discovery Steering Committee and Discovery Oversight Committee to oversee Discovery efforts. These committees' charges are to provide guidance for an inclusive, integrated, multidisciplinary research network that improves outcomes across the continuum of care for critically ill patients and their families.
Discovery provides several options for clinical investigators. First, during one of the several yearly meetings, including one at the National Institutes of Health (NIH) and one at the SCCM annual meeting, it takes calls for proposals. These proposals will be evaluated by members of the Discovery Steering Committee and the top proposals will be selected for oral presentation to the larger group. Other proposals will receive feedback and the possibility for poster presentation. Second, Discovery will provide networking abilities for clinical investigators to find potential collaborators and advisors. Finally, Discovery has yearly seed grant funding for clinical trials that are deemed likely to create new knowledge that will help patient care and be competitive for national and foundation grants.
Current Discovery projects include Programs for Emergency Preparedness (Discovery PREP), headed by Cobb, which examines how to rapidly collect data in the setting of a public health emergency; Observation of Variation in Fluids Administered and Characterization of Vasopressor Requirements in Shock (Discovery VOLUME CHASER), headed by Tina Chen, an observational trial examining whether the method of assessing fluid responsiveness in a patient with shock is associated with the amount of fluid delivered or with patient outcomes; and Severe ARDS: Generating Evidence (Discovery SAGE), headed by Pauline Park, which examines treatment of patients with severe acute respiratory distress syndrome. We will be entertaining additional proposals for our upcoming meeting at NIH in Bethesda, Maryland, USA, November 8–9, 2017. Please visit http://www.sccm.org/Research/Research/Pages/Discovery-Research-Network.aspx to submit your proposal.
Discovery is keen on determining how we might interact with other research networks to improve the care of patients with life-threatening illness and injury. We would like to congratulate the Saudi Critical Care Network on their meeting and look forward to exploring ways in which we might collaborate.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Finfer S, Vincent JL. Critical care – An all-encompassing specialty. N Engl J Med 2013;369:669-70.
Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, et al.
Protocols and hospital mortality in critically ill patients: The United States critical illness and injury trials group critical illness outcomes study. Crit Care Med 2015;43:2076-84.
Blum JM, Morris PE, Martin GS, Gong MN, Bhagwanjee S, Cairns CB, et al.
United States critical illness and injury trials group. Chest 2013;143:808-13.
Marshall JC. Global collaboration in acute care clinical research: Opportunities, challenges, and needs. Crit Care Med 2017;45:311-20.
Cobb JP, Ognibene FP, Ingbar DH, Mann HJ, Hoyt DB, Angus DC, et al.
Forging a critical alliance: Addressing the research needs of the United States critical illness and injury community. Crit Care Med 2009;37:3158-60.